The Grand Hotel Karel V is a hotel in Utrecht, Netherlands. It is located in the Duitse Huis complex of buildings, including part of the old monastery of the Bailiwick of Utrecht of the Teutonic Knights founded in 1348. Most of the rooms and suites are in a former military hospital, which dates from 1823 and has been carefully renovated, or in the modern Roman wing opened in 2008. The hotel contains a Roman-themed health center, conference rooms, a bar, brasserie and the Grand Restaurant Karel V. It is set in extensive grounds.